FAST DISSOLVING FILMS USING NATURAL AND SYNTHETIC POLYMERS CONTAINING DOMPERIDONE FOR THE TREATMENT OF ANTI-EMESIS
This study investigates the formulation and evaluation of fast dissolving films (FDFs) containing domperidone, an antiemetic drug commonly used to prevent nausea and vomiting. Especially for patients with difficulty swallowing or who require a rapid onset of action, fast dissolving films offer a convenient alternative to conventional tablets. For the preparation of the films, domperidone was incorporated uniformly within the polymer matrix using solvent casting. Various physicochemical properties of the formulations were evaluated, including thickness, weight uniformity, folding endurance, and a variety of other factors. Domperidone release profiles were also assessed in vitro using in vitro dissolution studies. Using domperidone fast dissolving films formulated with a combination of natural and synthetic polymers, this study demonstrates that fast dissolving films can effectively treat nausea and vomiting