44MICROWAVE MEDIATED SYNTHESIS OF SOME DIARYL PIPERIDINE-4-ONE DERIVATIVESA series of Diaryl piperidine-4-one Derivatives were synthesized by using microwave irradiation .The synthesis involves microwave irradiation of Ammonium acetate with montmorinollite K – 10 in a dry condition. Freshly distilled aromatic aldehyde, and ketone was added to the above mixture and then heated until colour of the solution turned yellow and left at room temperature overnight. The reaction was completed in 6-12 hrs with 40-50% yields and was environmentally friendly with easy to workup. The synthesized compounds were evaluated and its M.P’s were determined.sannidhikirankumar@gmail.comResearch312012Di aryl piperidine-4-one Derivatives,Proline, Montmorinollite K – 10,Anti neoplastic agent,ThiouroperoxidesKiran kumar S,G.sridharbabu,Naresh B,Kishore Kumar S,Praveen Kumar JampanaDepartment of Medicinal chemistry, Pragathi Pharmacy College, Jangaon, Warangal Dist., A.P, India.,Department of Medicinal chemistry, Pragathi Pharmacy College, Jangaon, Warangal Dist., A.P, India.,Department of Medicinal chemistry, Vikas College of Pharmacy, Jangaon, Warangal Dist., A.P, India.,Sri Nagarjuna College of Pharmacy, kazipet, Warangal, Andhra Pradesh , India.,Department of Medicinal chemistry, Acharya Nagarjuna University, Guntur Dist., A.P, India