47FORMULATION DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE OCULAR INSERTThe objective of present work was to develop ocular inserts of flurbiprofen and evaluate their potential for controlled ocular delivery. Conventional ophthalmic solution shows the poor bioavailability and therapeutic response due to many precorneal constraints. These constrains necessitates the controlled drug delivery to become a standard one in modern pharmaceutical era. Matrix type ocular inserts containing different combination of HPMC E 15 and Ethyl cellulose. The ocular insert were prepared by solvent casting technique and characterized thickness, hardness, weight variation, drug content, moisture loss, moisture absorbed, hydrolytic study, sterility study and In vitro release study. All the ocular inserts were found to be stable to all physiological studies. On the basis of In vitro studies, the formulation with HPMC E15 and Ethyl cellulose with concentration (3:7) was found to be better than the other formulations and provided the desired drug release In vitro for 36 h and remained stable and intact at ambient conditions.udshivhare@gmail.comResearch312012Ocular inserts,Flurbiprofen,Hydroxy propyl methyl cellulose (HPMC E15), Ethyl cellulose,In vitro studiesU.D. Shivhare,M.A.Chavan,K.P.Bhusari, V.B.Mathur,V.N.KakadeSharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110. (M.S.) INDIA,Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110. (M.S.) INDIA,Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110. (M.S.) INDIA,Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110. (M.S.) INDIA,Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110. (M.S.) INDIA