51FORMULATION AND STABILITY STUDIES OF CARBAMAZEPINE EXTENDED RELEASE TABLETSThe objective of this thesis work was to formulate and evaluate the extended release tablets, containing 200mg of Carbamazepine (5H-dibenz [b, f] azepine-5-carboxamide). Different excipients were tested for their compatibility with carbamazepine, which revealed that there is no physical and chemical interaction occurred. Extended release tablets were formulated by Wet Granulation method incorporating HPMC K4M. The release mechanisms of carbamazepine extended release tablets were evaluated. The thickness, hardness, friability, weight variation and drug content of the formulated extended release tablets were evaluated. Stability studies were carried out on the optimized formulation at 30ºC / 65% RH and 40ºC / 75% RH. The 3 Months stability results indicated that the selected formulation was stable and all the evaluated results were found to be satisfactory within the USP Limits.thulasiramaraju912@gmail.comResearch312012Carbamazepine,Hydroxy Propyl Methyl Cellulose (HPMC K4M),Wet Granulation method,Extended release drug delivery and Stability studiesT.V.Thulasiramaraju,A.Arunachalam,V.Pallavi,G.Venkatarami reddy,R.Senthil Raj,K.SrikanthA.M.Reddy Memorial College of pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutics, A.M.Reddy Memorial College of pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutics, ASN Pharmacy College, Tenali, Andhra Pradesh, India.,Department of Pharmaceutics, ASN Pharmacy College, Tenali, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Vikas College of Pharmacy, Jangaon, Andhra Pradesh, India.,A.M.Reddy Memorial College of pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.