54IN-VITRO ANTI OXIDANT ACTIVITY OF METHANOLIC EXTRACT OF ATALANTIA MONOPHYLLA LINN BARKThe free radical scavenging potential of Atalantia monophylla linn (Rutaceae) was studied by different antioxidant models. Free radicals are implicated for more than 80 diseases including Diabetes mellitus, arthritis, cancer, ageing etc. In the treatment of these diseases, antioxidant therapy has gained an utmost importance. Current research is directed towards finding naturally occurring antioxidant of plant origin. In Indian system of medicine, Atalantia monophylla linn is an important medicinal plant and it has been used in various ailments and as health tonic. To understand the mechanisms of pharmacological actions, the in-vitro antioxidant activity of methanolic extract of Atalantia monophylla linn bark was investigated for the activity of scavenging DPPH radical, nitric oxide radical and hydrogen peroxide radical. The in-vitro antioxidant activity the methanolic extract of Atalantia monophylla linn bark produced good antioxidant activity and was comparable with that of standard ascorbic acid. From which conclude the higher concentration of the methanolic extract exhibit more antioxidant activity when comparing to lower concentration. These results clearly indicate that Atalantia monophylla linn bark is effective against free radical mediated diseases. The data suggests that the extract contains compounds may be effectively utilized as a wide spectrum of antioxidant agent.satheesh.phyto09@gmail.comResearch312012Atalantia monophylla linn,Bark,Antioxidant,DPPH radical,Nitric oxide radical,Hydrogen peroxide radicalP. Satheesh Kumar,V. Kishor KumarDepartment of Phytopharmacy & Phytomedicine, JKKMMRF’s - Annai JKK Sampoorani Ammal College of Pharmacy, B. Komarapalayam – 638 183, Namakkal, Tamil Nadu, India.,Department of Phytopharmacy & Phytomedicine, JKKMMRF’s - Annai JKK Sampoorani Ammal College of Pharmacy, B. Komarapalayam – 638 183, Namakkal, Tamil Nadu, India.