59FORMULATION AND EVALUATION OF CARBAMAZEPINE EXTENDED RELEASE TABLETS USP 200MGThe objective of this research work was to formulate and evaluate the extended release tablets containing 200mg of Carbamazepine. Different excipients were tested for their compatibility with Carbamazepine, which revealed that there is no physical and chemical interaction occurred. Extended release tablets were formulated by Wet Granulation method incorporating HPMC K4M, a hydrophilic polymer, Dicalcium phosphate (Anhydrous) as diluent, Povidone (K-30) as Binder, Colloidal silicon dioxide (Aerosil-200) as Glidant, Hydrogenated Castor Oil (Boricin Pharma) and Talc as lubricants. Dissolution profiles were studied in Purified water as dissolution medium (900ml). The drug release were estimated at 3, 6, 12 and 24 hours by Ultra violet – Visible spectrophotometer (UV 1601, Shimadzu), at 284 nm. The influence of variables like polymer type, drug: polymer ratio on Carbamazepine profile release was studied. The release mechanisms of Carbamazepine extended release tablets were evaluated. The thickness, hardness, friability, weight variation and drug content of the formulated extended release tablets were evaluated. Based on the evaluation results, T9 (10% Methocel K4M) formulation was selected as the best formulation, reproducibility trials were taken and the results were found to be satisfactory.md.arif150@gmail.comResearch312012Carbamazepine,Hydroxy Propyl Methyl Cellulose (HPMC K4M),Wet Granulation method,Extended release drug delivery and EvaluationFasiuddin Arif Mohammed,A.Arunachalam,G.Venkatarami Reddy,V.Pallavi,SK.Moulali,T.V.Tulasi Rama RajuDr.Reddy’s Laboratories Limited, Bachupally, Hyderabad, Andhra Pradesh, India.,Department of Pharmaceutics, A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutics, ASN Pharmacy College, Tenali, Andhra Pradesh, India.,Department of Pharmaceutics, ASN Pharmacy College, Tenali, Andhra Pradesh, India.,A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.