63EFFECT OF VARIOUS SUPERDISINTEGRANTS ON THE DRUG RELEASE PROFILE AND DISINTEGRATION TIME OF METAPROTERENOL SULFATE ORALLY DISINTEGRATING TABLETSThe Demand for Orally Disintegrating tablets has been growing during the last decade. Metaproterenol Sulfate (orciprenaline sulfate) is a bronchodilator used in the treatment of Asthma, so development of an ODT of Metaproterenol Sulfate and to evaluate the effect of various superdisintegrants on its disintegration time and release profile was the prime objective of this research work. Tablets were prepared by Mass Extrusion Technique using three different superdisintegrants. Sodium starch glycolate, Avicel PH 102(Microcrystalline cellulose) and Low hydroxyl propyl cellulose (HPC) were used as superdisintegrants to achieve optimum release profile, disintegration time and hardness. The tablets were evaluated for weight variation, hardness, friability, in-vitro disintegration time and drug release characteristics. The hardness of all the formulations were almost uniform and possessed good mechanical strength. The wetting time in all the formulations was fast. In vitro release studies revealed that 97% of drug released from SSG, MCC (91%), and L-HPC (86%) for all the formulations were within 15 min. Based on above results, three formulations F3, F6, F9 were selected for stability studies these formulations showed not much variation in any parameter even after a the period of 30 days, formulations F3, F6, F9 were found to be stable and retained their original properties. Thus, it may be concluded that formulation containing sodium starch glycolate as superdisintegrants is fulfilling all the parameters satisfactorily. It showed excellent in vitro disintegration, in vitro dispersion time, compared to other superdisintegrants.pankajshukla367@gmail.comResearch312012Metaproterenol Sulfate,Rapidly Disintegrating Tablets,Sodium Starch Glycolate,Superdisintegrants,Mass Extrusion TechniquePANKAJ SHUKLA,,PANCHAXARI M DANDAGI,RINI THOMAS,SHARATH CHANDRA PDepartment of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, India,Department of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, India,Department of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, India,Department of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, India