655SYNERGISTIC EFFECTS OF CINNAMALDEHYDE AND HESPERIDIN AGAINST OXIDATIVE STRESS IN INDUCED TYPE-IDIABETESThe present study is hypothesized to investigate the beneficial effects of cinnamaldehyde and hesperidin on Type I Diabetes induced in rats by a single intraperitoneal injection of Streptozotocin (STZ) (65 mg/kg b.w.) in overnight fasting rats. An oral dose of cinnamaldehyde (20 mg/kg b.w.), hesperidin (50mg/kg b.w.) and their mixture was given for 4 weeks after diabetes induction daily. In the diabetic control group, levels of glucose, AST, ALT, creatinine, and blood urea nitrogen were significantly increased, while serum insulin, liver glycogen, total antioxidant capacity (TAC), glutathione peroxidase (GPx), and glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) activites were decreased. Treatment with cinnamaldehyde, hesperidin or their mixture significantly improves all these biochemical parameters in STZ-induced diabetic rats but the treatment with mixture of both cinnamaldehyde and hesperidin was more effective than treatment with cinnamaldehyde or hesperidin alone dr_fzahran@yahoo.comResearch682015Diabetes,Insulin,Streptozotocin,Cinnamaldehyde,Hesperidin,AntioxidantsZahran. FM,Al-Hussaini. AS,Abou-Mesalam. AI,Abou-Mesalam. AIChemistry Department, Faculty of Science, ZagazigUniversity, Egypt,Chemistry Department, Faculty of Science, Port Said University, Egypt,Chemistry Department, Faculty of Science, Port Said University, Egypt,Nuclear Medicine Department, Children’s Cancer Hospital – Egypt (CCHE - 57357), Cairo, Egypt