651QUANTITATION AND HPLC IDENTIFICATION OF FLAVONOIDS AND PHENOLICS OF FICUS RACEMOSA (L.) BUTANOL FRACTION AND IN VIVO ASSESSMENT OF ITS HYPOLIPIDEMIC AND HEPATOPROTECTIVE ACTIVITIES IN RATSFicus racemosa Linn. belongs to family Moraceae is used as herbal medicine from ancient times. Total phenolic and flavonoid contents of the dried powdered leaves were quantitated and exhibited 15.17% and 18.72%, respectively. Moreover, different extracts; (Distilled water, 70% ethanol and 95% ethanol) of F. racemosa (L.) leaves had been In Vitro assessed as antioxidants. The 95% ethanolic extract gave promising result, consequently, it was fractionated by solvents of increasing polarity and each fraction was screened as well. The butanol fraction was the most bioactive fraction (98.40%). High Performance Liquid Chromatography (HPLC) was used to identify and quantify the flavonoids and phenolics present in it. Further In Vivo assessment against Hyercholesterelemia and liver fibrosis in rats had been done. The butanol fraction exhibited higher antioxidant, hepatoprotective and hypocholesterolemia activities than the standard drugs. These observations were confirmed by the histopathological observationnagwaea@gmail.comResearch682015Ficus racemosa,Moraceae,Flavonoids,Phenols,Butanol fraction,Liver Fibrosis,HyercholesterolemiaNagwa E. Awad, Mostafa A. Abdelkawy,Manal A. Hamed,Maram M. AboshehataPharmacognosy Department, National Research Centre, Cairo, Egypt,Pharmacognosy Department, Faculty of Pharmacy, Cairo, University, Cairo, Egypt,Therapeutic Chemistry Department, National Research Centre, Cairo, Egypt,Pharmacognosy Department, National Research Centre, Cairo, Egypt