65SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF ISATIN DERIVATIVESSome new Synthesis of (N-carbamimidoyl 1-4-(2-oxo-1-(piperidine-1-ylmethyl) indolin-3-ylidineamino) benzene sulphonamide) has been synthesized from isatin & different p-substitute aniline. In the next step, I (a-h) on treatment with isatin, sulfanilamide and reflux with glacial acetic acid Synthesis of carbamimidoyl - 3 – (2-oxo-indalin-3 – yl- indene amino) benzene sulphonamide (a-h) In the last step, which on mannich reaction with piperidine and formaldehyde gave(Ncarbamimidoyl 1-4-(2-oxo-1-(piperidine-1-ylmethyl) indolin-3-ylidineamino) benzene sulphonamide) (a-h) under microwave irradiation at a power of 140 watts. MW irradiation led to higher yields in much less time than that by conventional method. The newly synthesized compounds were characterized on the basis of elimental analysis, IR, H NMR, and mass spectra. All the synthesized isatin derivatives have been investigated for their anti-inflammatory activity.bedadurgaprasad@gmail.comResearch312012microwave,conventional,synthesis,isatin,Mannich reaction,anti-inflammatory activityB.Durga Prasad,R.Vasanthi, B.Chandra Kanth,D.Prabhakar,M.Ram MohanDepartment of Organic & Medicinal Research Laboratory, Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar (dist)-505172. A.P, India,Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur (dist)-522510. A.P, India.,Department of Pharmaceutical Chemistry, KLR College of Pharmacy, Polancha, Khammam (dist)-507115. A.P, India.,Department of Organic & Medicinal Research Laboratory, Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar (dist)-505172. A.P, India,Department of Pharmaceutical Chemistry, Talla Padmavathi College of Pharmacy, Warangal (dist)-506002. A.P, India.